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Finally, it is important to note that hotspot TP53 missense mutations might have a distinct impact on the pathophysiology of cancer cells from that of truncating mutations or homozygous deletions which lead to absence of functional protein 59,61 , underscoring an additional layer of nuance when considering the role of tumor suppressor genes in PDAC

[DOI] [PubMed] [Google Scholar] 82.Ashoori M., Saedisomeolia A

Among the botanical drugs and polyherbal formulations reviewed, only Curcuma longa (Ali and Ali, 2013

J Exp Biol 224:jeb221606 Zhang R, Al-Lamki R, Bai L, Streb JW, Miano JM, Bradley J, Min W (2004) Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner

[41] showed that edaravone dexborneol effectively suppressed nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) inflammation-induced activation of microglial pyroptosis in experimental ischemic stroke through NF-B/NLRP3/gasdermin D (GSDMD) signaling pathway using transient MCAO (tMCAO) mouse model in vivo and oxygen-glucose deprivation (OGD) BV2 cell model in vitro