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Any clinical use, where lawful and available, requires individual assessment, supervision and monitoring by an appropriately qualified physician

Its key advantages are prolonged sterility (multi-dose use) and slight anesthetic effect, but it must be used correctly: always dilute drugs per guidelines, ensure the final solution is isotonic, and heed contraindications (no neonates, no intrathecal use)

Senescent cells of different types display a pro-inflammatory and matrix remodelling molecular programme, known as the senescence-associated secretory phenotype (SASP), which has roots in (epi)genetic changes

(2010) 5:e9808

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