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Given these mechanisms, IGF-targeted therapy lends itself as an attractive backbone to novel combination regimens as a strategy to prevent or overcome treatment resistance, and combinations that incorporate IGF-targeted agents with standard cytotoxic agents and/or other targeted therapies have been investigated preclinically in many human cancers (Table 3)

10.1038/nature08040 43 LuS

doi: 10.1101/cshperspect.a029025 257 Baecher-AllanCKaskowBJWeinerHL