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The molecule's central role in cellular function has made it an invaluable target for research into aging mechanisms, metabolic disorders, neurodegeneration, and research interventions aimed at promoting healthy longevity and optimal cellular function
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Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

doi: 10.1104/pp.103.2.621
CD38 is also important in acute lymphoblastic leukemia (ALL), an aggressive cancer of B or T lymphoblasts characterized by uncontrolled proliferation of immature lymphocytes [25]
