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doi: 10.1038/nchembio.2412

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This parallels the fatigue reported with GLP-1 agonists and semaglutide-specific tiredness

The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)