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B., Finney, L., Vogt, S., Witting, P

They also have a life expectancy of 79.1 years, are significantly less likely to attend routine health screenings, are more likely to delay seeking medical attention for concerning symptoms, and face higher rates of cardiovascular disease, type 2 diabetes, liver disease, and suicide

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60,61 A third redox-sensitive pathway groupincluding Wnt/-catenin, PI3K/AKT/mTOR, aryl hydrocarbon receptor (AhR), TGF-, calcium signaling, Janus kinase (JAK)/signal transducers and activators of transcription (STAT), hypoxia-inducible factor 1 (HIF1), NF-B, Nrf2, c-Jun N-terminal kinase (JNK), p38, and Ataxia-telangiectasia mutated (ATM)features components that shuttle between the cytoplasm and nucleus, allowing complex regulation of gene expression and cellular fate