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Indications of vitamin deficiency may include Fatigue Bone pain Muscle weakness Muscle aches Muscle cramps Poor sleep Depression or feelings of sadness Hair loss Loss of appetite Increased susceptibility to illness You should undergo vitamin level testing and take appropriate measures if your levels are low

If you are taking metformin, your healthcare provider may recommend additional vitamin B-12 supplementation, especially if you are on a high dose of metformin or if you have other risk factors for vitamin B-12 deficiency

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Insulin in the brain: there and back again