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doi: 10.1001/jama.2013.282834 34 ElingN.ReuterL.HazinJ.Hamacher-BradyA.BradyN

Furthermore, while JNK and its downstream targets c-Jun and ATF2 were activated during the early steps of the liver regeneration in wild-type animals, the constitutively active JNK found in the quiescent liver of Gstp1/2 knockout mice underwent a decrease in its activity after PH

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ALAN disrupts the expression rhythms of these genes within the SCN, leading to inaccurate or dampened timing signals from its output and, in some cases, a complete loss of circadian patterns (81, 82)

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