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Beyond the pancreas, GLP-1 receptors are expressed in the liver, adipose tissue, kidneys, and hypothalamus, which accounts for the drug class's broader effects on satiety, weight, inflammation, and renal protection.[4] The relevance to PCOS is direct: by improving insulin sensitivity and reducing hyperinsulinemia, GLP-1 receptor agonists lower the primary driver of ovarian androgen overproduction

Chatterjee, A., Tanoue, S., Houl, J

Furthermore, VPA reduces the release of the epileptogenic -hydroxybutyric acid and attenuates the neuronal excitation induced by N -methyl-D-aspartate (NMDA)-type glutamate receptors [9]

A large-scale study on the UK Biobank found no significant association between Thr92Ala carriage and symptomatic improvement, FT3 concentrations, or treatment preference, thus questioning its value as a predictive biomarker (45)

Not necessarily dangerous, but it needs medical oversight and close glucose monitoring