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B12 serves as a cofactor for enzymes that assist in the creation of methylmalonyl-coenzyme A (CoA) mutase and methionine, an enzyme required for metabolic processes and tetrahydrofolate production

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"GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration." BioMed Research International, 2015, 648108

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Just like if you have a problem with MTHFR and inadequate natural folate, problems occur when inadequate natural or coenzyme vitamin B12 exists

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