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10.1111/jebm.12342 61 LiJ.LiangQ.SunG

Fibroblasts obtained from ALS patients carrying the CHCHD10 mutation S59L display respiratory chain deficiency, ultrastructural alterations, and fragmentation of the mitochondrial network (Bannwarth et al., 2014

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Yang M, Chan HW, Yu LC

This metabolic impairment in neurons directly disrupts OXPHOS, resulting in elevated lactate levels and increased lactylation [65]