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10.1093/toxsci/kfl131 61 EdmondsB

Damage-associated molecular patterns (DAMPs) activate pattern recognition receptors, triggering the substantial release of pro-inflammatory cytokines (including IL-6, TNF-, and IL-1) and CXC chemokines 6

A central component in this response is the Ataxia-Telangiectasia mutated (ATM) gene, a serine/threonine kinase, which is activated in response to DNA double strand breaks 44

Hyperglycemia causes PKC activation and subsequent ROS production via NAD(P)H oxidase in cultured aortic smooth muscle cells [14]

From the periphery, the immediate defensive response can be the stable gastric pentadecapeptide BPC 157 therapy [1,2,3,4,5,6,7,8,9,10,11,15,27,28,29,30,33], peripherally and centrally