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Carnitine regulates myocardial metabolism by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha) in alcoholic cardiomyopathy

doi: 10.1023/A:1022465203458

Results Patient demographics and tumor characteristics The mean patient age was 67.5 years [standard deviation (SD) 7.3 years]

found that TMAO can inhibit the RCT process and affect cholesterol metabolism ( ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis ( coprostanol (a bacterial metabolite of cholesterol) ( Figure 3 Potential Therapeutic Measures of TMAO for AS Reduced Production of TMAO to Protect the Heart TMAO is an intestinal microbiota-dependent metabolite, which is accumulated in the body by ingestion of large amounts of substances rich in phosphatidylcholine

Jensen, MC