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IL-6 signalling exhibits both pro- and anti-inflammatory properties: it initially promotes the differentiation of macrophages and T- and B-lymphocytes, and later contributes to the resolution of inflammation 57
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Moreover, exogenous extracellular NAMPT was reported to promote the expression of profibrotic molecules in various types of renal cells [245,246], and an overexpression of endogenous NAMPT presumably induces glomerular inflammation and fibrosis [245]
Inhibition of GST-pi nuclear transfer increases mantle cell lymphoma sensitivity to cisplatin, cytarabine, gemcitabine, bortezomib and doxorubicin
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