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The nano-formulation restored mitochondrial dynamics through PIEZO1-PHB2-mediated regulation of PINK1/parkin-driven mitophagy, improved mitochondrial biogenesis, and alleviated excessive UPR caused by ER stress

Ultimately, the bottom-up approach recognizes the significance of local perspectives and actively involves those directly affected, making it a more inclusive and impactful strategy for the phase-out of mercury

Accordingly, experimental data indicate that proteins severely oxidized are more resistant to proteasome degradation (133)

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