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Although the rat GCLC promoter also contain a distal ARE 4 kb upstream [117], the 1.8 kb 5-flanking region of the rat GCLC does not contain any consensus ARE element (5-G/ATG/TAG/CNNNGCA/G-3) [105] and yet TBH treatment can induce the reporter activity driven by this 1.8 kb construct [118]

Because the K MGSSG values of GRs have been determined to be in the 1050 M range (Smith et al., 1989

[2] Research indicates that ALA may improve symptoms of diabetic neuropathy: for example, clinical trials and meta-analyses have shown that intravenous ALA (typically 600 mg per day for 3 weeks) may significantly reduce neuropathic pain, paresthesia, and numbness in diabetic patients