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Citrate is an abundant mitochondrial metabolite produced in an early TCA cycle reaction by citrate synthase from mitochondrial Ac-CoA and oxaloacetate (OAA)
NAD+ and the compounds discussed in this article target different systems, so they generally do not interfere with each other
(2018) demonstrated the effect of isolated chalcone on PC-3 cell lines, showing that cardamonin decreased the proliferation and viability of PC-3 cells through reduced expression of NF-B [190]
Nonetheless, MSCs have been reported to alleviate pain through multiple mechanisms 22
