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For confirmed B12 deficiency without neurological involvement , the standard regimen comprises 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks, followed by maintenance doses every two to three months for those with irreversible causes like pernicious anaemia

Yes, when administered by a trained professional, they are safe

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The conformation of the G2 loop in particular defines the active ON (GTP-bound) and inactive or relaxed OFF (GDP-bound) states