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Besides the already discussed actions of IGF-1 on glucose, it also has an indirect glucose-lowering effect secondary to its ability in increasing FA oxidation in muscle (will be further discussed in detail within the IGF - 1 and lipid metabolism section)

Tirsepatide treats type 2 diabetes and is also used to reduce weight

These are activated by leptin and secrete -melanocyte stimulating hormone (-MSH), which acts on second-order neurons present in the paraventricular area that express melanocortin 4 receptor(MC4R)

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The substantial weight reduction observed with tirzepatide monotherapy (15-21% body weight in clinical trials) suggests that any perceived benefits likely reflect tirzepatide's pharmacological effects rather than synergistic action