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Its primary role is to serve as a crucial defense mechanism, preventing harmful substances from entering the brain while facilitating the transport of essential nutrients to brain tissue [181]

The activation of the UPR begins by the dissociation of glucose-regulating proteins (GRPs) from three types of ER transmembrane anchors, namely inositol-requiring protein 1 (IRE1), activating transcription factor 6 (ATF6), or protein kinase RNA-like ER kinase (PERK) (6)

Importantly, somatopause is not a disease state

Mechanisms in COPD: differences from asthma

Rojas et al., 2014) in autism, though more recent reports failed to find Glu and GABA differences in autism(Brix et al., 2015