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Gastrointestinal Symptoms : nausea, vomiting, diarrhea, constipation, abdominal pain, reflux, heartburn, and impaired motility Secretomotor Symptoms : difficulty sweating, tearing, and other fluid production (dry eyes, dry mouth, difficulty swallowing, dry skin)

The strategy adopted is reported in a recent paper (72)

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Targeted neurotherapeutics face a challenge in penetrating the blood brain barrier (BBB) (Ballabh et al., 2004

While this may have partially biased our results, the baseline difference was not statistically significant, further strengthening the evidence for the efficacy of Sucrosomial B12