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Inhibition of sEH has been shown to decrease A production and deposition, improving cognitive outcomes in AD models ( Recent studies have shown that the gut microbiota plays a significant role in the development and progression of neurodegenerative diseases, including AD (Zhang et al., 2023)

Moreover, some NAD + precursors have shown side effects, such as the use of NA at certain doses that might be limited due to skin flushing or induction of insulin resistance 332,333

[DOI] [PubMed] [Google Scholar] Niemela O, Parkkila S, Pasanen M, Iimur Y, Bradford B, Thurman RG

[DOI] [PubMed] [Google Scholar] 82.Elsaed W.M., Mohamed H.A