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doi: 10.1089/cap.2009.0011

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Curcumin induced the ferroptotic death of breast cancer cells by upregulating HO-1 expression characterized by a marked accumulation of intracellular iron, ROS, lipid peroxides, and the downregulated GSH level ( Zingiber officinale Roscoe [Zingiberaceae

As shown in Section Riboflavin Ameliorates Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation, riboflavin has antioxidant properties and upregulates antioxidant enzymes especially SOD, also, supplementation with riboflavin will elevate the intra-mitochondrial FAD levels compensating for the decline in the capacity to assemble of dysfunctional mitochondrial complexes