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1 2 "Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B12"

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This knowledge also explains why oral B12 supplementation may be ineffective in intrinsic factor deficiency, requiring alternative routes like sublingual, nasal, or injectable B12 to bypass the intrinsic factor-dependent absorption pathway

The activation of these pathways can also induce the production of growth factors, such as TGF-beta and IGF-1, which promote fibroblast proliferation and collagen synthesis, enhancing the strength and repair capacity of the ligament