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Collectively, these findings suggest that HIF-1 is intricately involved in the proliferation, migration, and invasion of FLS in RA patients, alongside regulating angiogenesis and inflammatory responses

Clinical trials report notable increases in Lysholm scores (measuring knee function) alongside decreases in WOMAC and VAS pain scores following treatment

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Furthermore, metformin was shown to mitigate the effects of testosterone-induced hormone receptor expression, and restore testosterone and HOXA10 expression levels (Ohara et al., 2021)