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Alterations in mitochondrial DNA copy number and the activities of electron transport chain complexes and pyruvate dehydrogenase in the frontal cortex from subjects with autism

37 Current studies further demonstrated that HIF-1 inhibited two enzymes in FAO, the medium- and long-chain acyl-CoA dehydrogenases MCAD and LCAD

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However, rather than directly affecting FAO, SCAP deficiency suppressed regulation of genes involved in sterol biosynthesis, including critical enzymes such as 3-hydroxy-3-methylglutaryl coenzyme A reductase

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