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Ascorbate and glutathione: Keeping Active Oxygen Under Control

Unfortunately, as we age, our levels of glutathione may not be sufficient to fight all of the damage being done by the increasing amounts of free radicals due to pollution, diet, aging, increased amount of medications, stress, and trauma

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Thus for drugs known to undergo enterohepatic recirculation, the need for therapeutic drug monitoring may be necessary to ensure optimal dosing and to avoid adverse effects

Sousa AR, Lane SJ, Cidlowski JA et al (2000) Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor -isoform