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In copper-based catalytic systems, sustained GSH-driven copper redox cycling can generate hydroxyl radicals (OH), causing acute oxidative damage and inducing apoptosis in cancer cells 183-185

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10.7501/j.issn.1674-6376.2024.03.009 51 KonishiT.KondoS.UchiyamaN

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Patient education is equally vital

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Clinically, LOAD begins with episodic memory decline and gradually advances to involve executive dysfunction (Kelly et al., 2020) language disturbances (Paolini Paoletti et al., 2021) and impaired daily living (Guo et al., 2022)

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