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One possible hypothesis is based on the ability of the SARS-CoV-2 virus to cross the blood-brain barrier and reach the brain, or that the virus may reach the brain via the hematogenous route 11

Using targeted excision of the IGF-1 receptor in the growth plate, this study demonstrates that growth hormone can directly promote bone elongation in the absence of locally acting IGF-1 and IGF-2

Pyrrolidine dithiocarbamate prevents p53 activation and promotes p53 cysteine residue oxidation

Zaccolo and Movsesian, 2007

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