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Biomarker changes do not establish broad clinical benefits

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While MdDS has been classified as a rare, disabling disease, with the wide interest in cruises, there is a steady stream of patients who contract this illness

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However, the relevance of this mechanism may extend to a variety of cell types, including other cells that can produce NO, such as endothelial cells and neurons, and cells exposed to NO in the microenvironment 17,19,49

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A can directly disrupt the ETC and interfere with various mitochondrial matrix proteins and putative components of the mPTP, ultimately resulting in mitochondrial dysfunction (77-80)

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The inclusion and exclusion criteria for each included study are detailed in Supplement Table 3

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