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First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism

On the other hand, for the L-NAME retrobulbar applicationinduced retinal ischemia model and BPC 157 therapy in rats, we should emphasize the point that animal studies per se may be cautious regarding their results, although the role of an animal model is indispensable (Vestergaard et al., 2019)

T.HaseS.IkegamiM.ShibataD.et al

Providers should not make long-term practice decisions predicated on an outcome that has not yet occurred

Now heres the funny bit The MHRA in responding to our petition stated: Vitamin B12 could not legally be classified as a medicine that can be made available for sale without prescription in pharmacies because it is an injection and because the condition it is licensed to treat, pernicious anaemia, needs a clinician to diagnose it, and monitor its treatment (see point IV above)