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Although originally described as an ATP-dependent enzyme, recent work has demonstrated that TPK1 can utilize several nucleotides as phosphate donors for the phosphorylation of thiamine

Glutathione is produced by our own bodies (neat!), and is made up of three amino acids

It regulates healthy brain nerve cell functions and supports healthy neurochemical balance.*

The gene has approximately 2000 known mutations and all of them affect in some degree the protein function, which makes the pathophysiological manifestations to be multisystemic, mainly affecting the respiratory, gastrointestinal, endocrine, and reproductive tracts

Additionally, because low NAD+ is linked to aging, its decline could contribute to the development of various age-related health concerns, including cardiovascular disease, metabolic disorders, the development of neurodegenerative diseases such as Alzheimers and Parkinsons, and cancer