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Yet, the long-term effects of these changes are unknown ( Therefore, more information is needed concerning long-term supplementation, particularly when high doses are used

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Human liver P450s 3A4, 2C9, 2D6, 2C19, 1A2, and 2B6 are responsible for about 75% of all clinically relevant phase I drug metabolism ( Figure 44 ), and thus for about 60% of all physiologic drug biotransformation and elimination

Hepatology 2025;81:1595-1606

The goal is simple: help practices make better clinical decisions with less guesswork and stronger long-term patient oversight
