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10.1021/acs.biochem.0c00658 Summary Keywords 7-hydroxymitragynine, functional selectivity, kratom, Mitragyna speciosa, mitragynine, opioid receptor signaling, positive allosteric modulation, structure activity relationship Citation Hemby SE, Rangel-Grimaldo M, McIntosh S, Zheng J, Flores-Bocanegra L, Graf TN, Coover RA and Oberlies NH (2026) Multifaceted modulation of human opioid receptors by kratom alkaloids: binding affinity, functional selectivity, and allosteric activity
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