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In corneal fibroblasts treated with oxidants, the level of ALDH3A1 carbonylation increases 23 fold, suggesting that high concentrations of corneal ALDH3A1 may serve as a direct target for ROS and reactive aldehydes and thereby provide a passive protective effect for other proteins [29, 31]

The process of germination is a natural phase in the growth of seeds, contributing to an improved texture and the addition of valuable metabolites to the seed (Imam et al., 2013)

In light of natural compounds that can act on immune checkpoints and have the advantage of reducing chemotherapeutic side effects, its combination with ICIs may enhance the efficacy and reduce related irAEs, thereby assisting in cancer chemoprevention

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doi: 10.3892/ijo.2025.5730 173 LeeJWJPlichtaDHogstromLBorrenNZLauHGregorySMet al