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It should be clarified that although the contribution of immune cells to metabolic diseases is mainly concentrated in AT, an effective source of such inflammation also exists in the liver, intestines, and other metabolic regulatory tissues, promoting the production of inflammation and obesity throughout the body through the circulation (131)

[DOI] [Google Scholar] 85.Coxeter P.D., Duke C.C., Roufogalis B., McLachlan A.J

Ruchaud, S

Patient satisfaction was moderate

It was initially proposed that the stabilization of the hypoxia-inducible factors (HIFs), caused by the fumarate-dependent inhibition of prolyl hydroxylases, was instrumental for tumour formation 3,4