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For instance, 4-HNE and oxidized phosphatidylethanolamines derived from ferroptotic glioblastoma cells upregulate IL-12 and TNF- in infiltrating macrophages, a feature not observed in hepatoma or colorectal models [153]

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Complementary strategies include convection-enhanced delivery (CED) systems that enhance parenchymal drug distribution and chemical modifications (e.g., lipid group conjugation) to improve drug lipophilicity for BBB transit [109, 110]

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