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Exacerbations should be treated using a high dosage targeted antibiotic therapy,3,4 due to the fact that the volume of distribution and total body clearance for hydrophilic drugs (such as aminoglycosides, penicillins, and cephalosporins) are increased because these patients are generally undernourished and have decreased adipose tissue

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These cytokines recruit additional immune cells, amplifying inflammation and tissue damage

Kong P, Cui ZY, Huang XF, et al

239 showed that glutathione depletion constitutes one mechanism of ferroptosis