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what the actual preclinical metabolic studies measured and found

This is because pernicious anemia is not simply a vitamin B12 deficiency but an autoimmune condition that prevents the body from absorbing vitamin B12 in the gut, even when it is available

A 24-week randomised controlled trial published in The Lancet enrolled 203 obese adults and tested three doses (0.25mg, 0.5mg, 1.0mg daily) against placebo

PubMed: 11700589 AOD 9604 Effects on Visceral Adiposity, Metabolic Syndrome, and Insulin Sensitivity in Obese Mice animal Shen Y, Liu B, Duong T, et al