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Recent prospectively designed studies have found higher WC increases CVD risk in older adults [27, 28], whilst meta-analyses demonstrate increased risk of incident dementia following obesity in mid-life, but a reduced risk when obesity is developed in older adulthood [29, 30]

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The IC 50 (half maximal inhibitory concentration) and Hill coefficient ( h ) for inhibition of NMDA-evoked currents with Li + were estimated by fitting of concentrationresponse curves with the Hill equation, I = I min + (I max I min )/(1 + [Li + ] h /IC h 50 ), where the I max and I min are the current of maximal and minimal amplitudes elicited by NMDA at different [Li + ]

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