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Blood bicarbonate levels are also typically lower in people who have Addisons disease (chronic adrenal insufficiency), in which aldosterone levels are reduced, and in people who have renal damage, such as chronic nephritis

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3.4 FOXO4-DRI alleviates OGD-induced endothelial cell senescence We investigated the effects of FOXO4-DRI on OGD (oxygen-glucose deprivation)-induced senescent endothelial cells by treating them with PBS and FOXO4-DRI

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