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The Khavinson-group data in transgenic cancer-prone mice actually shows reduced tumor burden, which argues against this but anyone with active malignancy or strong family history of cancer should be especially careful and work with appropriate medical oversight

Bloodbrain barrier dysfunctioninduced inflammatory signaling in brain pathology and epileptogenesis

The human evidence is limited

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If you are curious about whether tirzepatide lasts as long as the label suggests , proper storage is the single biggest factor