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Early studies on therapeutic vaccination have focused on preventive recombinant vaccines, such as hepatitis B vaccines containing HBsAg

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14 The vascular defects observed in LPAR4 and LPAR6 double-knockout mice, including impaired vascular sprouting, defective tip cell formation, disrupted branching morphogenesis, and embryonic lethality, directly implicate LPA-LPAR signaling in promoting endothelial cell migration, proliferation, and network formation during vessel sprouting

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