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On day 10 after inoculation, tumor-bearing mice were treated with vehicle (saline), APR-017(100 mg/kg per day, ip., for 10 days), IC261(0.6 mg/kg per day, ip., for 10 days), or APR-017 + IC261, and tumor growth was monitored via in vivo imaging (IVIS)

[DOI] [PubMed] [Google Scholar] 125.Major JM, Laughlin GA, Kritz-Silverstein D, Wingard DL, Barrett-Connor E

Bachta et al

All reagents for redox assays were supplied by either Sigma-Aldrich Chemie (Taufkirchen, Germany) or Sigma-Aldrich, Inc

The central nervous system effects contribute primarily to nausea and reduced appetite, which are both therapeutic mechanisms and potential side effects depending on severity