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A series of recent studies implicated sirtuins as potent negative regulators of fibroblast activation and myofibroblast differentiation, and sirtuin dysfunction has been linked to the pathogenesis of SSc and other fibro-inflammatory conditions 28,29,38,39,40,41,42

Many of the side effects can be avoided by increasing water consumption and avoiding caffeine

[DOI] [PMC free article] [PubMed] [Google Scholar] 254.Stein C., Hassan A.H., Przewocki R., Gramsch C., Peter K., Herz A

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