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As glutamine is derived directly from the astrocytic TCA cycle (Figure 1) sufficient TCA cycle activity is also a prerequisite for sustained astrocyte glutamine synthesis (Fonnum et al

These often massive shell mounds (the Emeryville Shellmound was originally reported as being 60 feet (18 m) high by 350 feet (110 m) long), were often built up over centuries of shell discards and showed a stable source of easily obtained shellfish utilized for many hundreds of years

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