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Contactinduced apical asymmetry drives the thigmotropic responses of Candida albicans hyphae

Transient Ca 2+ influx facilitates OXPHOS and ATP production, whereas prolonged influx disturbs several dehydrogenases of the TCA cycle and ATP synthase and triggers increased opening of mitochondrial permeability transition pores (mPTPs), which damages OXPHOS to burst ROS and form a positive feedback loop between Ca 2+ and ROS, where ROS enhances Ca 2+ influx and vice versa, initiating glycolysis to activate the M1 phenotype [74, 75]

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How they work in the body is briefly explained below

10.1016/j.anai.2012.01.014 74