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Moreover, it has been stated that in reality, all human beings present autoantibodies interfering in immunoassays (specific IgG4 anti-immunoglobulin autoantibodies) [1,2]

Finally, there's physical agitation and light exposure

Because piracetam derivatives are often presented as more potent than piracetam and are not licensed for medical use, however, we have classified these substances as similar to 4-phenylpiracetam

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Targeting other glycolytic enzymes has proved beneficial in additional chemoresistant cancers: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) targeting by miR-488 reduced glucose uptake and increased sensitivity to 5-FU in colorectal cancer (Deng et al., 2021), PKM2 targeting by miR-122 decreased glycolysis and led to increased sensitivity to 5-FU in colorectal cancer (He et al., 2014) and in doxorubicin resistant liver cancer (Pan et al., 2016), and LDH targeting by siRNA knockdown or an inhibitor increased sensitivity in paclitaxel resistant breast cancer and showed synergy in combination with paclitaxel (Zhou et al., 2010)