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Conclusion Demonstration of effective and safe lowering of plasma p-tau181 with SAMe in this phase II trial would pave the way for an exciting field of translational research and a larger phase III trial.

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Use of stomach acid-resistant capsules (DRcaps) further protect stability

Various causes, including exogenous and endogenous stress factors, an imbalance between prooxidants and antioxidants, disruption of antioxidant pathways, and gene polymorphisms, lead to the overproduction of reactive oxygen species

This study provides a novel, holistic evaluation of their physicochemical and biomedical properties, paving the way for scalable synthesis and potential applications in sustainability and healthcare