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You dont always need both, but many people benefit from a combination, especially during high-demand seasons like pregnancy, breastfeeding, or chronic stress

Completely different mechanisms

doi: 10.1080/10408363.2021.1885339 4

Efficacy and tolerability of a fixed dose combination of methylcobalamin and pregabalin in the management of painful neuropathy

Over 7 days, thats 30 mg/day 7 = 210 mg/week